In Scientology, the auditor bears a significant responsibility for the progress of his subject.
A significant responsibility for this disparity of treatment still lies with an overwhelmingly white, middle class and male magistracy and judiciary, resistant to ethnic monitoring, which hides behind the fallacy that justice is "colour blind and impartial".
Above all of these disparities may have a significant responsibility for such a high prevalence of obesity and overweight in the People's Republic of China.
In this post-Enron era, the media has a significant responsibility to provide careful, accurate coverage of the accounting procedures companies use to verify their results.
Survival of young sheep (and other animals) was vital to maintaining the pastoral-nomadic way of life, and a significant responsibility for Mongol women was to coax the ewes to nurse their young.
In my mind, I have not a shadow of a doubt that Blair shoulders a significant responsibility in every drop of blood spilt in Iraq and Afghanistan, as it was he who backed ideologically driven Bush all the way regardless of what everyone, including his own country, said.
Family caregivers have a significant responsibility in the care of their child in the Pediatric Intensive Care Unit (PICU).
Discussing not only the importance of putting together balanced juries to ensure fair judging of the awards, Lions Festivals CEO, Philip Thomas highlighted that the juries had a "significant responsibility in determining the future path of creative communications".
In the face of opportunity, anyone who joins the startup is thrust into a role of significant responsibility — it comes with the territory.
"I've found that a subset of these founders, when you put them in positions of significant responsibility, flourish and they bring that sort of founder's mindset, that customer focus, that impatience," says Mr Donahoe.
