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The phrase "a significant response" is correct and usable in written English.
It can be used when discussing the importance or impact of a reply or reaction in various contexts, such as research, surveys, or discussions.
Example: "The study received a significant response from participants, indicating strong interest in the topic."
Alternatives: "an important reply" or "a notable reaction."
Exact(60)
First, tonotopic responsive areas were detected as areas with a significant response to auditory stimuli.
A significant response would be expected".
"This is a significant challenge to which we expect the BBC to make a significant response".
Not surprisingly, there was a significant response and not all were totally serious.
The positive control, IL-6 also induced a significant response (p < 0.001).
I raised this subject on Twitter where it received a significant response among professional researchers, academics and students.
Under 365 nm LED illumination, xerogel 2 + 3 showed a significant response whilst xerogel 1 + 3 did not.
The gain of the chemotactic system is large: the change in occupancy of one receptor molecule produces a significant response.
Only flying carabid beetles showed a significant response to both wetland restoration and creation.
The index registered a significant response to the causes of eutrophication and its symptoms.
Almost all (18/21) of the genes showed a significant response to P. luminescens strain TT01.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com