Sentence examples for a significant remodelling from inspiring English sources
In 1820 the portico that still stands at the theatre's front entrance on Catherine Street was added, and in 1822 the interior underwent a significant remodelling.
Taken together, these results indicate a significant remodelling process regarding the P. pastoris cell envelope during ER stress conditions.
Thrombin is known to have a significant remodelling effect over endothelial junctions, by acting through several pathways including small GTPases for review [ 36].
Smaller tumours (2-5 mm diameter) were characterized by a significant remodelling of their stroma, including a depletion of fibrillar collagen and α-smooth muscle actin (α-SMA -positive fibroblasts.
Brain enlargement in primates has been paralleled by a significant remodeling of the mitochondrial proteome.
The decrease of the nucleus width and height below a value of 6 ± 1 μm can only be compensated for by a considerable increase of the nucleus length indicating a significant remodeling of the cell nucleus content.
It is noteworthy that not only changes to the mitochondria, but also a significant remodeling of the ER proteome, in particular a remarkable upregulation of protein disulfide isomerases PDIA4 and PDIA6, was recently reported in cisplatin-resistant A549 cells.
These data show that diseased myocytes can undergo significant remodelling of t-tubular structure with a loss of radial directed t-tubules and an increase in oblique and longitudinally oriented t-tubules.
The cumulative probability plot in figure 4 shows that a number of IP joints (n = 12) showed significant remodelling over 12 months (change of total score greater than the SDC, in this case ≥36).
Accordingly, significant remodelling of the CNS occurs during larval and pupal development and a vast number of additional cells are generated during a second wave of proliferation.
Preeclampsia, the most common pregnancy-associated pathological syndrome, is accompanied by significant remodelling of the extracellular matrix and alteration in lipid composition of the umbilical cord artery (UCA).
