Sentence examples for a significant remodeling from inspiring English sources
Brain enlargement in primates has been paralleled by a significant remodeling of the mitochondrial proteome.
The decrease of the nucleus width and height below a value of 6 ± 1 μm can only be compensated for by a considerable increase of the nucleus length indicating a significant remodeling of the cell nucleus content.
It is noteworthy that not only changes to the mitochondria, but also a significant remodeling of the ER proteome, in particular a remarkable upregulation of protein disulfide isomerases PDIA4 and PDIA6, was recently reported in cisplatin-resistant A549 cells.
In 1820 the portico that still stands at the theatre's front entrance on Catherine Street was added, and in 1822 the interior underwent a significant remodelling.
Taken together, these results indicate a significant remodelling process regarding the P. pastoris cell envelope during ER stress conditions.
Thrombin is known to have a significant remodelling effect over endothelial junctions, by acting through several pathways including small GTPases for review [ 36].
Smaller tumours (2-5 mm diameter) were characterized by a significant remodelling of their stroma, including a depletion of fibrillar collagen and α-smooth muscle actin (α-SMA -positive fibroblasts.
For example, ADH2 has a repressive chromatin structure under high glucose conditions, with significant remodeling of the nucleosomes upon activation (unpublished data), [28].
The stability of the individual NLP species assembled with B. mori apoLp-III was monitored for 5 months, which revealed significant remodeling of the smaller NLP species to a consensus structure with an average diameter of 20 nm.
Thus, significant remodeling of the active site has not occurred as a result of the Asp insertion, and the key catalytic residues remain appropriately positioned for catalysis.
Suppression of ERβ resulted in significant remodeling of the actin structure within the REN cells, with a transition from a largely cortical actin polymerization pattern to a highly defined stress fibers organization.
