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Although autonomic regulation is clearly a significant regulator of the HRV power spectrum, evidence demonstrates a lack of concordance with direct evaluation of sympathetic tone, for example in patients with heart failure [ 45], and reviews increasingly conclude that HRV is generated by multiple physiological factors, not just autonomic tone [ 46, 47].
A conclusion can be that drowning out HA is a significant regulator of CaOX supersaturation and thus a regulation of CaOX stone formation in human urine.
SUR2A is a significant regulator of myocardial resistance to stress whose expression is regulated by mild hypoxia in vitro [20].
Because CLIC4 is indicated as an integral part of the cellular stress-response pathway and is a significant regulator of cell apoptosis and growth in live cells, we hypothesize that the regulation of CLIC4 protein expression may affect ATP-induced apoptosis.
Recently, hypothalamic kisspeptin-GPR54 signaling has emerged as a significant regulator of this neuroendocrine axis.
In the cytosol, dynamic regulation of the m1A modification on tRNAs in response to metabolic cues is a significant regulator of cellular protein synthesis37.
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This supports that Cbl-b, but not Cbl, is a physiologically significant regulator of osteoclast in vivo.
DOI: http://dx.doi.org/10.7554/eLife.07217.003 To determine if Nur77 is a physiologically significant regulator of bone, we next examined the in vivo skeletal phenotype of Nur77 KO mice.
We selected fascin for this analysis, because syndecan-1 is a functionally significant regulator of the cytoskeletal organization of actin and fascin in several normal cell types [ 28, 36].
In the present study, we show that RA patients frequently develop autoimmune response to TIMPs that may act as a functionally significant regulator of MMP activity and thereby of joint destruction.
In particular, a pair of methylmalonyl CoA mutase (mcm) genes involved in polyketide precursor biosynthesis, an acyl-CoA dehydrogenase implicated in timing of actinorhodin synthesis and bldB, a developmentally significant regulator whose mutation causes complete abrogation of antibiotic synthesis belong to this category.
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