The phrase "a significant refinement of" is correct and usable in written English.
It can be used when discussing improvements or enhancements made to a concept, process, or product.
Example: "The latest version of the software includes a significant refinement of its user interface, making it more intuitive for users."
Alternatives: "a notable improvement in" or "a considerable enhancement of".
A significant refinement of the javelin was the Roman pilum.
A significant refinement of this technê is found in Cicero's On Ends.
The addition of Zr to the Mg 2.4Zn 0.1Ag 0.1Ca alloy resulted in a significant refinement of the grain size.
In a significant refinement of methods, we focus on providing public input to institutional practice and governance of biobanks using a tailored workbook structure to guide participants' discussion.
An increase of the atomic fraction of Cr induces a significant refinement of grain sizes, from ∼100 nm for a Cu96Cr4 alloy to ∼30 nm in the case of a Cu20Cr80 alloy.
Increasing the solidification rate results only at mould thicknesses of 4 mm and below in a significant refinement of the particle microstructure, necessitating liquid metal deposition techniques to utilise it for obtained improved mechanical performance of HMS.
The second method can be viewed as an extension of the first one by using a new descent direction which provides a significant refinement and improvement of the first one.
While Labor's Mark Dreyfus described it as a "significant refinement and a narrowing" of the proposed bill and spoke in support of the "unanimous" report, the text made it clear some committee members still felt the bill had significant legal problems.
When Voight published his prediction mechanism, USGS geologist Robert I. Tilling praised it for being "a significant refinement in the interpretation of monitoring data".
This integration of adhesion and aggregation functions are a significant refinement over past platelet substitute designs.
With increasing current density, pH of the bath and saccharin content, there was significant refinement of the grain structure.
