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The phrase "a significant rationale for" is correct and usable in written English.
It can be used when explaining the reasoning or justification behind a particular decision, action, or belief.
Example: "The study provides a significant rationale for implementing new educational policies to improve student outcomes."
Alternatives: "a substantial reason for" or "a compelling justification for".
Exact(1)
A significant rationale for identifying RCC-associated hypermethylated TSGs is their potential role as biomarkers to identify high-risk individuals and presymptomatic tumours by analysis of urine samples (Battagli et al, 2003; Hoque et al, 2004).
Similar(58)
That is quite a significant rationale in acquiring Argos".
Significant rationales for these collaborations include the high expectations placed on rapid and front-edge technology development and business exploitation.
Significant rationales for these innovation collaborations include the high expectations placed on rapid and front-edge technology development, better access to resources, and business exploitation (Goerzen 2007; Laperche and Liu 2013).
An important rationale for cloning an An.
Although this might be interpreted as a significant result, the rationale for choosing a one-tailed test might be debated.
"I believe that after the significant changes in curricula, qualifications and systems of accountability, there is a very strong rationale for a significant period of stability to allow these changes to bed in.
These significant, functionally meaningful associations provide a powerful rationale for prioritizing the testing of the 17 IDE variants for association with LOAD beginning with these two expression SNPs (eSNPs).
A significant and clinically relevant improvement in these parameters would provide a solid rationale for performing a subsequent trial testing histological improvement.
Significant tensile stresses can be generated locally along certain directions, which offers a mechanistic rationale for the internal cracking observed experimentally.
These comprised the following wording (with associated judgmental criteria provided per domain - details in Table 1): Domain I (Rationale): Would a significant body of accredited homeopaths support the rationale for the intervention used in the study?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com