The phrase "a significant question of" is correct and usable in written English.
It can be used when discussing an important issue or topic that requires consideration or analysis.
Example: "The study addresses a significant question of how climate change impacts biodiversity."
Alternatives: "an important issue of" or "a crucial matter of".
A significant question for auditors of brokerage firms to evaluate is whether the brokers are subject to consumer protection rules specifying what can be done with customer money, and, if so, whether they are in compliance with the rules.
The location of the 1963 Yalova Earthquake is a significant question since the rupture of this event and western termination of the 1999 Izmit Earthquake are debated (Muller et al. 2006).
If he is healthy — a significant question given the seriousness of his neck condition and the long rehabilitation it has entailed — Manning remains one of the few quarterbacks so dominant he can instantly transform a franchise.
Thus, a significant question remains whether the choice of diet (as well as sex of animals or background genetics) could potentially complicate the potential for translation [ 19- 21].
John Holme London Whatever the jury's conclusions in the Mark Duggan inquest, there remains a significant question mark over the training of the gun specialists in the police force.
The timeline remains a significant question amid reports that members of the Trump administration had known about Porter's alleged history for months and that the allegations prevented Porter from getting a full security clearance.
A significant question that arises is the preparedness of mining engineering education in Africa to address the vision of the mine-of-the-future in relation to these four focus areas.
A significant question concerns the hydrogen-bonding property of the OH group on the Y5 ring, which could interact favorably, albeit transiently (under conditions of dynamic hydrogen-bond exchange), with lipid heads groups and interfacial water molecules.
However, the mechanism underlying the axonal-regrowth-promoting effect of BMD remains a significant question.
Ever since that afternoon, I've been on a mission to categorically answer the awkward but significant question of exactly what we'd do if we could magically rewind our careers.
