The phrase "a significant question about" is correct and usable in written English.
You can use it when introducing a topic or issue that is important or noteworthy for discussion or analysis.
Example: "In today's lecture, we will explore a significant question about the impact of climate change on global agriculture."
Alternatives: "an important question regarding" or "a crucial inquiry into".
But it does raise a significant question about the political venture capitalists: what if, in the future, they decided not to support Democrats at all? Suppose there came along an independent candidate, free from the baggage of Democratic Party politics, who espoused with conviction the kind of agenda that donors of the Phoenix Group or America Coming Together really wanted to hear?
The authors of the study, which was published Tuesday in the journal Health Affairs, said it highlighted a significant question about the new federal health care law: can access to primary care be maintained, much less improved, when an already inadequate and inefficient system takes on an expected 32 million newly insured customers?
Aside from the tuning angles of the custom plates and the never-been-used-before foam, Nike must show that its technology can answer a significant question about human potential.
There's a significant question to be answered about why it is so difficult for the national institutions, whether it's policing or education, to recognize black people as part of the polity".
Second, there should be no significant question about a nominee's ethics, particularly as they affect performance on the bench.
The most significant question about a doubleheader that day would be what time the second game would start.
Until recently, few researchers challenged the paradigm; the only significant question about consolidation seemed to be how long it took for the cement to dry.
Fresno State, Hawaii and Nevada will join Boise State in the Mountain West in 2012, and will play out the string in a Western Athletic Conference facing significant questions about its future.
The shadow Defence Secretary, Liam Fox, said Mr Brown had been "woefully slow" to provide British troops with the equipment and claimed that his visit had failed to answer a number of significant questions about the British mission in Afghanistan, including the supply of Ridgeback armoured vehicles.
Lord Black of Brentwood, chairman of PresBof, said: "The imposition by the privy council of a royal charter on our industry raises hugely significant questions about a free press, a free society and the quality of our democracy.
Scottish Labour welfare spokeswoman Jackie Baillie said: "Whilst the number of households with children in temporary accommodation is decreasing, the fact that there are a thousand more such households now than a decade ago raises significant questions about how the SNP government is trying to tackle homelessness.
