The phrase "a significant progression" is correct and usable in written English.
It can be used to describe a notable advancement or improvement in a particular context, such as personal development, technology, or research.
Example: "The study showed a significant progression in the participants' skills over the course of the training program."
Alternatives: "a notable advancement" or "a considerable improvement."
In 13 hips (8%, CI: 5 14 13 patients (10%, CI: 6 17)—a significant progression of the pseudotumor was evident, while in 4 hips (3%, CI: 0.1 7)—4 patients (3%, CI: 0.1 8)—there was a retrogressive change.
This in itself is a significant progression – when Dubbo first hosted the Knockout in 1984, the Daily Liberal local newspaper spoke of an "influx" of Aboriginal people, and after some trouble in town, ran sensationalised stories and provocative headlines.
This work, therefore, represents a significant progression in exploitation of MN for successful transdermal delivery of a much wider range of drugs.
This tool has seen a significant progression in the field of critical care over the last 10 years, particularly in the case of central venous line insertion, echocardiography, and ultrasound of the lung.
Of them, 77 (31 %) patients had a significant progression of LS.
Over the 10-year period, 69.6% of patients showed a significant progression in total radiographic score (≥ MCID).
11 Subgroup analyses of the EGFR wild-type population showed a significant progression-free and overall survival benefit (progression-free survival HR 0.78, 95% CI 0.63 0.96, P = 0.0185; overall survival HR 0.77, 95% CI 0.61 0.97, P = 0.0243).
Although the 40983 study did not show a significant progression-free survival benefit with peri-operative chemotherapy on an intention to treat basis, an improvement in progression-free survival of 9.2% at 3 years was seen in those patients who achieved surgical resection.
Conroy et al. showed that a gemcitabine-free triplet combination, FOLFIRINOX (5-fluorouracil [5FU], irinotecan, and oxaliplatin) achieve a significant progression-free survival (PFS) and OS benefit compared to gemcitabine alone in patients with metastatic PAC in a randomized phase II/III [ 8].
Considering our definition of progression, two patients in the placebo group and one patient in the treatment group showed a clinically significant progression.
The lack of a definition of clinically significant progression and how to use it practically may be a disincentive to performing frequent examinations.
