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The phrase "a significant production" is correct and usable in written English.
It can be used to describe a production that has considerable importance, scale, or impact, often in the context of theater, film, or other artistic endeavors.
Example: "The theater company is known for its commitment to quality, and their latest play is expected to be a significant production that will draw large audiences."
Alternatives: "an important production" or "a major production".
Exact(45)
The deal is the latest in a series of tie-ins and expansions by Netflix, which is becoming a significant production player rather than just a streaming platform.
This leads to a significant production decline causes the problems of pump failure/underperformance, severe liquid/solid loading etc.
In addition, in children, the only strain inducing a significant production of specific IgA at oropharingeal level was KP.
There will be time for the company and its supporters to grapple with these issues; for now there is a significant production of a Telemann opera to savor.
A significant production of N2O was, however, also found in the anaerobic reactor, thus indicating a probable occurrence of the denitrifying phosphate accumulating organism activity.
In the territory of Piazza Armerina (Enna) the presence of streams full of water allowed, since the 14th century, a significant production cycle mainly related to the wheat cultivation and grinding.
Similar(15)
From Wikipedia to Open Source Software, Peer Production – a large-scale collaborative model of production primarily based on voluntary contributions – is emerging as an economically significant production model alongside firms, markets and governments.
Airlines benefited from a sharp decline in the price of oil after Saudi Arabia and Iran sent a strong signal of significant production increases.
Dendrimer ABP alone induced only a modest and non-statistically significant production of IL-6.
The non-water-wet systems all exhibited a significant tail production of oil.
Our data also showed a significant cell production of VEGF and nitric oxide.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com