The phrase "a significant problem with" is correct and usable in written English.
You can use it when discussing an issue or challenge that is considerable in nature, often in a formal or analytical context.
Example: "There is a significant problem with the current approach to waste management that needs to be addressed urgently."
Alternatives: "a major issue regarding" or "a considerable challenge with".
The report identified a significant problem with the way in which fossil-fuel stocks were priced.
"We have a significant problem with female voters," said John Weaver, a senior Republican strategist.
"I don't think the real estate industry has a significant problem with the base wage," Mr. Rothschild said.
The Sierra Club, the United States Fish and Wildlife Service, and the Audubon Society all recognize bird mortality as a significant problem with wind generators.
The Personal Health column "Added Sugars Are Taking a Toll on Health" (Sept . 12 highlights a significant problem with addressing nutritional issues in the United States.
Dannatt expressed significant concerns about equipment, saying the controversial "Snatch" Land Rover was "significantly exposed" in Iraq and that there was a "significant" problem with helicopters.
He expressed significant concerns about equipment, saying the controversial "Snatch" Land Rover was "significantly exposed" in Iraq and that there was a "significant" problem with helicopters.
But an I.R.S. spokesman, Don Roberts, said the existence of the guide did not imply that the agency thought it has a significant problem with cheating by consultants.
Asked whether he expected to uncover a significant problem with drugs, border crossings or terrorism in northern North Dakota, Mr. Stanton said no one was sure.
This is not a problem with either hot water or steam systems, but it can be a significant problem with forced-air systems.
Dannatt this morning expressed significant concern about equipment, saying the controversial "Snatch" Land Rover was "significantly exposed" in Iraq and that there was a "significant" problem with helicopters.
