The phrase "a significant problem when" is correct and usable in written English.
It can be used to introduce a discussion about a specific issue that arises under certain conditions or circumstances.
Example: "There is a significant problem when the data is not accurately collected, leading to flawed analysis."
Alternatives: "a major issue when" or "a considerable challenge when".
Speaking at the RSA security conference in San Francisco in April, Cerrudo said many firms selling smart systems were failing to build in effective security, such as encryption – a significant problem when so many services transmitted their data wirelessly.
Have we introduced a significant problem when we teach students to judge values, standards, and beliefs critically?
Correlating among diverse sources like workstations, various application servers, and the network can be a significant problem when facing Big Data challenges.
This poses a significant problem when the issue at stake is quite literally a humanitarian one.
Being busy and over-scheduled is a significant problem when it comes to our health and well-being.
Communications capability alone between the State Department, U.S. aid and defense (representing governance, nation building and security respectively) poses a significant problem when classified computer and voice-based systems are incompatible or need complicated firewalls to establish basic connectivity.
In addition, differential stress increased with depth in the Linxing region, which indicates that wellbore instability might be a potentially significant problem when drilling wells that are vertical or ∼ N-S-trending.
This selection was intended to reduce false polymorphisms caused by the alignment of paralogs, a potentially significant problem when aligning short sequence reads.
This requirement is intended to minimize the discovery of false polymorphisms due to the alignment of paralogs, a potentially significant problem when aligning short sequence reads.
With A.C.T., the marker virtually cannot chop paintballs which is a fairly significant problem when upgrading 98s for high rates of fire, this upgrade kit will cost you an additional $35.
This is an especially significant problem when defending against information operations, because many organizations holding valuable information are comparatively small organizations with limited security budgets.
