The phrase "a significant problem to" is correct and usable in written English.
It can be used when discussing an issue that poses a considerable challenge or difficulty to someone or something.
Example: "The lack of funding presents a significant problem to the success of the project."
Alternatives: "a major issue for" or "a considerable challenge to".
Summer high temperatures affecting urban areas pose a significant problem to human health.
While the crack in the turbine blade may just be a minor flaw, he said, it is unlikely to pose a significant problem to continuing the program.
This poses a significant problem to attempts of accelerating convolution of huge images on GPU.
"You are seeing renewed interest from venture capitalists, corporate investors and foundations in recognizing that we have a significant problem to solve.
"The US and South Korea stand shoulder to shoulder, both in face of Pyongyang's provocations and our refusal to accept a nuclear North Korea". He said both he was encouraged that Beijing - believed to have the most influence on Pyongyang - was beginning to recognise that North Korea was "not just a nuisance but a significant problem to their own security".
Immunological rejection of neural transplants poses a significant problem to be overcome in order to conduct successfully stem cell-based cell therapy in human patients.
Access to medicines in developing countries continues to be a significant problem due to lack of insurance and lack of affordability.
To date, CINV remains a significant problem contributing to patient withdrawal from potentially curative chemotherapy [ 5, 8- 10].
A significant problem pertaining to many attacks is that it is impossible to detect them (unless they break connectivity or disrupt the 'expected' functionality).
Even if one assumes that the current environment may lead to reduced enforcement activity over time, having those policies and systems in place will redound to the benefit of the company if a significant problem were to arise.
I possess a fairly nice stereo (not a problem) and some 2,500 CDs (a significant problem, according to my wife), but the biggest problem is the custom-built cabinet I commissioned to house my music.
