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The phrase "a significant problem that" is correct and usable in written English.
You can use it when introducing a major issue or challenge that needs to be addressed or discussed further.
Example: "The report highlights a significant problem that affects the overall performance of the organization."
Alternatives: "a major issue that" or "a critical concern that".
Exact(40)
The photo ID requirements of the present bill are a significant problem that cannot be dismissed or ignored".
Stephen Lloyd Senior partner, Bates Wells & Braithwaite London LLP The Guardian's investigation into offshore secrecy highlights a significant problem that is global in its impact.
Apple, which has gone from laggard to leader, said that it "is making a conscious decision to be more transparent and expansive in its sustainability efforts, including those directly related to climate change, as we believe it's a significant problem that may affect our operations, suppliers, partners and customers, and we are taking action to address it".
Payroll is the biggest single cost item for operators, he adds, accounting for about 60% of their overheads: "So when the minimum wage increases without a corresponding increase in fees for care, it is a significant problem that will threaten the viability of many homes if it continues".
Mr. Cordray, in testimony before the House committee, said his agency had determined over the summer that the restriction of credit to stay-at-home spouses was "clearly an unintended consequence" of the CARD Act and was creating a significant problem that must be addressed.
The owners' plan was meant to solve a significant problem that emerged Thursday: the sides were at odds over how long it should take for the players union to re-form, which was necessary for a collective bargaining agreement to be completed and the lockout to end.
Similar(19)
When gastric reflux occurs more frequently and past the age of seven weeks, it becomes a clinically significant problem that is diagnosed as pediatric gastroesophageal reflux disease (GERD).
What Hume's arguments do show, however, is that while it is possible that the reality of evil is consistent with the existence of God this leaves theism with a large and significant problem that remains unanswered.
Drivability is an important problem that creates a significant level of discomfort and loss of customer acceptance in road vehicles.
Grand challenges are defined as significant problems that need a long term, coordinated approach from researchers to overcome.
This is a significant problem area that has been virtually unnoticed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com