The phrase "a significant problem as" is correct and usable in written English.
It can be used when introducing a discussion about a problem that is important or noteworthy in relation to a specific context or situation.
Example: "The lack of funding has become a significant problem as it hampers our ability to complete the project on time."
Alternatives: "a major issue as" or "a considerable challenge as".
Outsourcing is a significant problem, as well as undocumented workers holding a huge percentage of jobs in the service sector!
Under most circumstances, a short week wouldn't be a significant problem as long as both teams deal with the same schedule.
This is in contrast to the ICU, where the progression to ARDS appears to be a significant problem (as high as 44%).
Assignment of either exposed or unexposed individuals to the wrong category can be a significant problem, as can combining individuals with low and high levels of exposure into one group.
An emerging theme from several groups is that this is not a significant problem, as long as one bears in mind that human cellular systems take an inherently long period of time to acquire functional maturity, compared with their rodent equivalents [ 30].
For the structural monitoring of railway bridges, electromagnetic interference (EMI) is a significant problem as modern railway lines are powered by high-voltage electric power feeding systems.
Non-significant differences in dental care use may not be a clinically significant problem as long as children are receiving appropriate dental care.
Falls and fall-related injuries in the elderly constitute a significant problem for individuals as well as for society.
"We also see a trend of doctors, perhaps more in A&E than GPs, failing to properly consider the implications of a patient with diabetes when managing what might otherwise be a significant problem, such as infection or a fracture, which can lead to complications and problems that might otherwise be avoided".
Since, Acinetobacter species bear similar systems; emergence of resistance during treatment might be a significant problem for this genus as well.
The slide notes that "ineffectual" Iraqi police forces have been a significant problem, and cites as a concern sectarian conflicts between Iraqi security forces.
