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The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly.
Germ-line mutations of KMT2D are associated with Kabuki syndrome, an autosomal dominant disease characterized in part by immunological defects, but without a significant predisposition to lymphomas.
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Paracchini et al. [12] reported that haplogroup O-M122-derived lineages (O3 in their paper) were associated with a statistically significant predisposition to prostate cancer in their Japanese sample.
The SS and SX groups of the African patients showed a statistically significant predisposition to aCCP seropositivity compared with the XX group (SS group vs XX control group: OR = 7.01, P = 0.0121; SX group vs XX control group: OR = 6.4, P = 0.0223), and RF was also more prevalent in the SS and SX groups compared to the XX control group, although the difference was not significant (Table 5).
However, it is a common opinion that ligament tears and secondary joint laxity lead to significant predisposition to articular cartilage degeneration secondary to altered knee forces.
Chronic exposure of swine industry workers to airborne barn dust results in significant predisposition to airway diseases and impairment of alveolar macrophage (AMϕ) function.
There was no significant predisposition to these operative procedures between the two groups.
The Predominance of Verbal and Imagery-based Thoughts VAS (Section 5.5.7) has been used with bipolar patients to demonstrate a significant predisposition towards imagery-based processing styles (Holmes et al., 2011).
Increasing evidence suggests that there is a significant genetic predisposition to cerebrovascular disorders, and these genetic risk factors may account for some portion of the unexplained risk of stroke [ 1– 4].
While familial risk factors account for a significant rate of predisposition to schizophrenia, there is evidence of an important environmental contribution [ 17, 32].
Ligase IV syndrome is a rare differential diagnosis for Nijmegen breakage syndrome owing to a shared predisposition to lympho-reticular malignancies, significant microcephaly, and radiation hypersensitivity.
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