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The phrase "a significant population" is correct and usable in written English.
It can be used when discussing a large or important number of individuals within a specific group or area, often in contexts like demographics, research, or social issues.
Example: "The study revealed that a significant population of the city is affected by the new policy changes."
Alternatives: "a large demographic" or "a considerable number of people."
Exact(60)
Moreover, our Monte Carlo simulation predicts a significant population inversion.
They recently detected a significant population of pulsars in the globular cluster.
A significant population of our students come directly from undergraduate schools.
e360: You mentioned China's aim of greening its economy despite a significant population of impoverished people.
A significant population of nanoparticle aggregates exhibited characteristic dimensions below 50 nm.
It also has a significant population of older European nationals, drawn by the heat and relatively low cost of living.
Without a significant population at poverty level, Cheshire had not qualified for Title I money for years.
The district is also about 25percentt white, which includes a significant population of Orthodox Jewish voters.
All but one of the patients were women of color; the surrounding area has a significant population of African immigrants.
Situated just east of New York City, Suffolk County has a significant population of immigrants, both documented and not.
Though not included in the CSEA-defined job-seeking pool, entrepreneurs are a significant population within the Stanford MBA class.
More suggestions(15)
a significant majority
a significant demographic
a young population
a finite population
a significant loss
a traumatised population
a significant shift
a dense population
a frightened population
a significant contribution
a significant offer
a Initial population
a significant case
a controlled population
a homogeneous population
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com