The phrase "a significant origin of" is correct and usable in written English.
It can be used when discussing the source or starting point of something that has considerable importance or impact.
Example: "The ancient river systems are considered a significant origin of early agricultural practices in human history."
Alternatives: "a major source of" or "a key starting point for".
These limited data suggest that foods of animal origin are a significant source of human exposure, but inhalation and dust may also be important.
Region of origin was not a significant source of effect modification for lack of recent cervical cancer screening.
The provision of safe drinking water is a global issue, and animal production is recognized as a significant potential origin of human infectious pathogenic microorganisms within source water catchments.
There were 442 transcripts with a significant lineage-of-origin effect on gene expression.
We therefore tested all loci with a significant parent-of-origin effect to determine whether the effect is due to a maternal genetic effect or genomic imprinting.
Overall, transcripts with a significant lineage-of-origin effect on gene expression were associated with chitin binding (P = 0.003) and carbohydrate binding (P = 0.003) (Dennis et al. 2003).
There was a significant parent-of-origin effect on seed weight in reciprocal diploid hybrids, although this effect on seeds was not obvious in the reciprocal tetraploid hybrids.
A significant parent-of-origin effect was not observed when Su z 12 4 was combined with Su var)2-5 05 ; the only exception was hb where the trend was the reverse of Su var)2-5 05 andne, and the levels did not exceed wild-type.
The BP analysis discovered a significant parent-of-origin-specific genome-dosage effect on stress-response genes, with several stress-response terms significantly overrepresented in the genes upregulated in the 3x(p) F1 triploid, including both biotic and abiotic stress responses (Supplementary Table S2).
A subsequent GLM on PC1 scores, with origin as a between-subjects factor (and replicate group as blocking factor), resulted in a significant effect of origin (F 1,27) = 10.22, P = 0.004); for PC2 the assumptions of homogeneity and normality were violated so we performed a Mann-Whitney U test, which yielded a non-significant effect of origin (U = 122, N1 = N2 = 16, P = 0.821).
