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The phrase "a significant one for" is correct and usable in written English.
It can be used to indicate that something holds importance or relevance for a particular subject or context.
Example: "This event is a significant one for our community, as it brings people together to celebrate our shared heritage."
Alternatives: "an important one for" or "a meaningful one for".
Exact(40)
Last year was a significant one for China Miéville.
"This is one, but a significant one for us, more than just the win.
The past year has been a significant one for women – and girls with sporting dreams – in Australian sport.
Despite the tentative nature of the day's events, the decision was a significant one for the council, appointed by America's civilian administrators last month.
An important win for Miami, and a significant one for the whole AFC, too, as it keeps Denver in pole position for the conference's No1 seed.
The question is a significant one for Research in Motion, the company that makes the BlackBerry and is now introducing a new consumer variation, the Pearl.
Similar(20)
The move is a significant one both for Apple and Amazon.
The problem of relapse in depression is a significant one and for many individuals depression is a chronic relapsing condition.
The deal is a significant one not just for the 16-year-old company but for the UK's tech scene as a whole.
Although this is not a new story, it is a significant one, having ramifications for both prices and the level of turnover".
In a letter to assembly men and women the Presbyterian church said it was "not merely an issue of conscience for Christian people and churches, but a very significant one for the whole of society".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com