The phrase "a significant obstacle of" is not correct in standard written English.
It is typically used to describe a major barrier or challenge related to a specific subject or issue, but the preposition "of" is not appropriate in this context.
Example: "The lack of funding is a significant obstacle to the project's success."
Alternatives: "a significant barrier to" or "a major challenge in".
Development of an accurate in vitro model of the brain remains a significant obstacle to our understanding of the functioning of the brain at the tissue or organ level.
A significant obstacle to implementation of GDF is public and political concern around risks and consequences of failure against design criteria over the 10 to 10 year required lifespan of the facility, highlighted by several failures to site GDF repositories, e.g., in the UK and at Yucca Mountain in the USA.
This is a significant obstacle for implementation of RE policies.
Indeed, in an age where computer-accessible databases promise to facilitate research and learning, the permissions requirement can stand as a significant obstacle to realization of that technological hope.
The Second Circuit's decision makes for a more predictable legal environment for foreign central banks that choose to maintain reserves in New York and presents a significant obstacle to creditors of a country who look to central bank assets in the United States to collect on unpaid judgments.
Indeed, given the costs associated with MRI and the dose-limiting effect, ARIAs pose a significant obstacle for development of certain mAbs.
On the other hand, because such antigens are subjected to a great evolutionary pressure, a high level of sequence heterogeneity is expected within natural populations, which may constitute a significant obstacle to development of effective vaccines.
This has been a significant obstacle for analysis of CD70 in pathologic specimens because most archival tissues are preserved as FFPE samples, in which existing anti-CD70 antibodies fail to work.
The company hopes that it will reduce populations of disease-carrying mosquitoes by 80% but public opposition to anything "genetically modified" remains a significant obstacle to the possibility of saving thousands of lives.
Lack of an adequate number of genetically engineered plant lines for evaluation of anticipated traits presented a significant obstacle to genetic engineering of V. rotundifolia.
