Exact(4)
"We really see Branch Avenue becoming a significant node of TOD activity," Albert said.
We also determined that Interferon signaling was significantly affected by A20 overexpression in the liver, with type II Interferon (IFNγ) being a significant node.
We identified ERK1/2 as a significant node in the IEG response to ET-1, particularly with respect to positive regulation of RNA expression, whereas RhoA has a less significant role with positive and negative effects (Figs. 3 and 4).
Choosing for each node, the class for which it turned out to have a significant node score, we evaluate its Jaccard-score (J = tp/ tp+fn+fp), where tp is the number of true positive cases, fn the number of false negative cases and fp the number of false positive cases).
Similar(56)
Our data identify ERK1/2 as a more significant node than RhoA in regulating the early stages of cardiomyocyte hypertrophy.
3O-C12 has been shown to elicit the production of IL-8 from fibroblasts and corneal epithelial cells [21], [30], and the IL-8 gene was upregulated 47-fold in the microarray analysis of A549 cells stimulated with this ligand [33], so it was unsurprising that the gene was found to be a statistically significant node in the network analysis of this data set (Figure 2).
The genes identified, PRKG1, SLC24A3 and SLC8A1, influence the vascular tone likely through an increase in the concentration of cytoplasmic calcium (Ca2+), and may represent a significant key node for systemic BP regulation.
Biological themes as represented by GO-terms (biological processes, molecular functions and cellular compartments) fulfilling the following criteria were included into further analysis: 1. Number of underlying genes per GO-term >9 2. No terms of lower hierarchy clearly contributing to a significant higher node (e.g. exclusion of "collagen V" if "collagen" is significant) 3.
The maximum value of 1 denotes that all the network loads are lost due to a certain node removal while there is no load loss for the minimum value of 0. That is, the power grid can maintain the normal operation after taking out a non-significant node.
We suggest this may be the case for the trait of extractable soil aluminum in the current study, as it had a K statistic of less than unity (K = 0.80 with marginal significance of p = 0.09; Table 2) and node-specific results from the AOT showed a number of significant nodes associated with high aluminum.
In addition, two protein structures share a significant seven-node motif (ID 151803784262302).
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