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The phrase "a significant new" is correct and usable in written English.
You can use it to refer to something that is important, noteworthy, or distinct. For example, "This report reveals a significant new finding about climate change."
Exact(59)
There was, though, a significant new difference.
In their absence, however, is a significant new partner.
It marks a significant new direction for Malawi's tourist industry.
Critics say the policy has created a significant new loophole.
But with each year, campaigns attract a significant new audience.
"But it's a significant new step in protecting right whales".
"The new clothes demonstrate a significant new relationship between man and technology," he wrote.
On my reading, Foreman should raise the curtain on a significant new generation.
In this context, eSports may well represent a significant new revenue stream.
It is a dramatically improved document that may signal a significant new direction at Agriculture.
Until this year, the company has not introduced a significant new drug in a decade.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com