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The phrase "a significant negative deviation" is correct and usable in written English.
It can be used in contexts such as statistics, finance, or research to describe a notable departure from an expected or average value in a negative direction.
Example: "The analysis revealed a significant negative deviation in the company's quarterly earnings compared to projections."
Alternatives: "a considerable adverse deviation" or "a marked negative variation."
Exact(1)
A case-only analysis among all cases from the case-control and family materials (ESM Table 5) supported a significant negative deviation from multiplicative effects, with weaker ORs conferred by PTPN22 in the HLA risk categories (3 df test for interaction; p = 0.028).
Similar(59)
The Houpt Townsend SIC statistic (Houpt & Townsend, 2010) indicated three participants had a significant positive SIC, one participant had a significantly negative SIC, and two participants had neither significant positive nor significant negative deviation, but did have a significantly positive MIC.
Six out of nine loci (Saxgra-06, Saxgra-10, Saxgra-16, Saxgra-22, Saxgra-23, and Saxgra-38) showed significant negative deviations from Hardy Weinberg equilibrium (HWE) based on calculations of inbreeding coefficient GIS, performed with 9999 permutations.
In contrast, the probability of mortality showed a significant negative relationship with deviations of weight.
"This could have a significant negative impact".
Sulgrove as West now had a significant negative clue.
NH4NO3 has a significant negative effect.
We observed a significant negative correlation between leukocytosis and hypokalemia.
Job satisfaction had a significant negative impact on turnover intentions.
Trees generally had a significant negative effect on maize yield.
ADHD may have a significant negative impact on academic performance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com