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The phrase "a significant move in" is correct and usable in written English.
It can be used to describe an important action or decision taken in a particular context, often related to strategy or progress.
Example: "The company's announcement of a new partnership is seen as a significant move in expanding its market reach."
Alternatives: "a major step in" or "an important action in".
Exact(28)
Steve Clarke and Neil Lennon also feature prominently on the bookmakers' list after a day of fast-moving events that has seen Palace's relegation odds take a significant move in the wrong direction.
Neither made a significant move in the off-season.
Absenting a significant move in the gold price, management's options seem fairly limited.
It was a significant move in terms of personnel but was primarily a tactical change.
"We've been waiting for two years for a significant move in the renminbi, and we haven't got one," he said.
"He is exactly the calibre of player we should be bringing into this club and a significant move in terms of our recruitment process.
Similar(32)
Stanley F. Druckenmiller, who managed Mr. Soros' flagship $8.2 billion Quantum Fund, made a significant move into technology stocks in the middle of last year.
Rory McIlroy was left to rue a series of missed putts as he failed to make any significant move in a frustrating third round at the US Open.
The ability to bridge the world of Google Talk and Skype with legacy systems like Polycom is a significant move forward in video conferencing technology.
In a significant move, the Supreme Court in India has questioned the very basis of counting the poor in the country.
This is a significant move for Twitch in terms of growing its creator community, and therefore its wider user base.
More suggestions(16)
a significant evolution in
a vital move in
a large move in
a major move in
a substantial move in
a huge move in
a tremendous move in
a sizable move in
a smart move in
a significant partner in
a significant change in
a significant time in
a significant reduction in
a significant rise in
a positive move in
a significant character in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com