Exact(6)
GATA2 was present in a significant module for the colon cancer (published in 2011) dataset.
For example, we detected NFKB2 and BCL3 in a significant module for the breast cancer (2002) dataset.
Consistent with the expected ranalexin induced stress, a significant module (p ≤ 0.027, 3/3 nodes RanaUp) contained chaperones and stress response genes.
Interestingly a significant module (p ≤ 2.38E-5 7/15 GO:0009405) had 15 known two-component sensors or regulators, and a further four poorly characterised genes which may form novel virulence-associated two-component systems.
A significant module (p ≤ 0.046, 3/6 nodes RanaUp) contained the opuC osmoprotectant transport operon (SAR2535-SAR2538); osmoprotransporterssporters are thought to be strongly dependent on σB induction [ 78, 82].
Each run produces what is in effect a partition of the set of all nodes, with each partition being a significant module, except the largest partition which consists of all nodes not in significant modules.
Similar(54)
The biological interpretation of a statistically significant module (sub-network) is that the products of a set of genes associated to the disease also interact physically, thus raising the possibility that they belong to the same pathway or biological process.
Furthermore, the training for the psychotherapist certificate includes family therapy as a very significant module.
For the Pink and Red modules, we found a highly significant module preservation measure (r = 0.53 p < 10e-03) and (r = 0.51 (p < 10e-03), respectively, which shows that these modules are highly preserved between the two strains.
Module detection followed by a meta-analysis on chronological age identified fifteen consistently coexpressed PPI modules associated with chronological age, including a highly significant module (P = 3.5 × 10−38) enriched for ' T-cell activation' marking age-associated shifts in lymphocyte blood cell counts (R = 0.603; P = 1.9 × 10−10).
A highly significant module (p ≤ 1.9E-4, 7/12 nodes RanaDown) included five ESAT-6 components; the sixth MRSA-252 ESAT-6 gene (esaA, SAR0280) was not assigned to a module but was RanaDown and shared edges with 10/12 genes in the module.
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