The phrase "a significant modulation of" is correct and usable in written English.
It can be used in contexts where you are discussing a notable change or adjustment in a particular variable or condition.
Example: "The study revealed a significant modulation of the participants' responses based on the varying stimuli presented."
Alternatives: "a notable alteration of" or "a considerable adjustment of".
A significant modulation of band gap is observed for a certain type of zigzag nanotube upon varying concentration of di-vacancy.
Examination of OfCXCR4 transcriptional regulation post injection to different stimuli or pathogens revealed a significant modulation of mRNA expression as detected by reverse transcription-quantitative real-time PCR.
The results reveal that Ni-doping introduces a significant modulation of the electronic structures, such as the density of states, HOMO LUMO gaps and the d-band centers, which dominate their chemical activities towards CO2 adsorption.
The skin permeation studies demonstrated a significant modulation of the transdermal melatonin permeation for hydrogels prepared with redispersible nanocapsules.
The texture signal was associated with a significant modulation of firing rate.
We show that when subjects were observing arm movements there was a significant modulation of beta oscillations overlying left and right sensorimotor cortices.
We did not observe any significant modulation of ERK phosphorylation under these conditions (Fig. S1).
Finally, a significant modulation in expression of genes related to cellular proliferation and differentiation was observed.
Further, our results demonstrated a significant modulation in the expression of 49 key metastasis-regulating protein targets of these metastamiRs in aggressive cells ex vivo and in the manifold of metastatic tumors in vivo.
In our previous studies we could verify a significant modulation in the secretion of these proteins in IL1β-stimulated HACs.
In particular, 31 out of 54 neurons (57%) showed a significant modulation in MOV, and 31 out of 54 (57%) in HOLD (anova, P < 0.05).
