Exact(5)
A significant Mixture ingestion X Sex interaction on Nbm amplitude and a significant Mixture ingestion X Sex X Hemisphere interaction on Pam latency were observed.
The data, Dr. Baines said, indicated that the bright surface areas, which had been thought to be mostly pure water ice, appeared to contain a significant mixture of contaminants.
At modulation period of 8.6 nm, XRD pattern showed a significant mixture of strong ZrN (111), W (110), as well as weak ZrN (220) textures.
A significant mixture effect was recorded at a dose below the response thresholds for each component.
We excluded studies if the proportion of non-eligible participants were greater or equal to 20% of the total population to prevent a significant mixture with disease or interventions that are not included in the present review.
Similar(55)
Even under these circumstances, a highly significant mixture effect of more than 50% was observed.
Although a realistic exposure assessment for EDCs in the marine environment is still missing, it is conceivable that even very low concentrations of these compounds can contribute to an overall significant mixture effect, as confirmed in this and other mixture studies (Brian et al. 2005; Silva et al. 2002; Thorpe et al. 2003, 2006).
In all cases, significant mixture effects ranging from 28 to 99% of a maximally possible effect were observed, and these effects could be predicted quite accurately by application of the dose addition concept.
There is evidence that dissimilarly acting agents, when combined at doses below their NOAELs, may also produce significant mixture effects (Table 5).
The studies listed in Table 5 demonstrate the induction of significant mixture effects with dissimilarly acting chemicals combined at levels below their NOEL.
On reviewing the low-dose mixture literature, we found good evidence demonstrating significant mixture effects with combinations of chemicals well below their individual no observable adverse effect levels (NOAELs), both with mixtures composed of similarly and dissimilarly acting agents.
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