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The phrase "a significant misunderstanding" is correct and usable in written English.
It can be used to describe a misunderstanding that is important or has considerable implications.
Example: "The meeting revealed a significant misunderstanding regarding the project's objectives, which we need to address immediately."
Alternatives: "a major misconception" or "a considerable misinterpretation."
Exact(9)
Mr. Bostock fired back in a letter saying that Mr. Icahn's argument "reflects a significant misunderstanding of the facts about the Microsoft proposal and the diligence with which our board evaluated and responded to that proposal".
"What is occurring now is either a significant misunderstanding or a misinterpretation of the facts," said William A. Gollnick, a high-ranking Oneida official on the reservation just west of Green Bay, Wis.
"It reflects a significant misunderstanding of the theatrical arts, and it does not give credit to Patricia for the remarkable job she's done to make this organization recognized not just across New York, but nationally".
The Internet portal's chairman, Roy Bostock Roy Bostock, fired a letter back to billionaire investor Carl Icahn late Thursday, correcting what he termed a "significant misunderstanding" over the details of the takeover talks between Yahoo! and Microsoft.
In general, no understanding was defined as a lack of relationship between what the patient was told and what they reported, poor understanding was defined as a significant misunderstanding that could potentially lead to harm, adequate understanding was defined as a misunderstanding that was not expected to result in harm, and excellent understanding was defined as having no gaps in knowledge.
Commonly made arguments that there are no transitional fossils and that there are no examples of macroevolution (see Mead 2009 for a thorough discussion of common misconceptions of evolution and the fossil record) show a significant misunderstanding of evolution in geologic time.
Similar(50)
The potential for even more significant misunderstanding was underscored last weekend when a quick, seemingly perfunctory telephone call by Mr. Obama returning the congratulatory call of Poland's president led to a dispute about what was said about missile defense.
All the errors are less than 1.5%, which would bring no significant misunderstanding of attenuation structure.
Kabir and his fiancée experience significant misunderstanding in the meanwhile, which they soon overcome.
Following several years characterized by significant misunderstanding in the US - Egypt bilateral relationship, Egypt must once again resume its role as a reliable and steady US partner in a tumultuous region, supporting Egypt in the fight against terror.
There are also significant misunderstandings that result from him writing her a love poem that falls into the hands of her husband.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com