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Currently, maintaining the Alawites in power is a significant matter of national security for Iranian leaders.
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There was also the significant matter of a 100th cap for another Welsh Williams - flanker Martyn - who avoided what he described as the "pain" of being left stranded on 99 caps.
Later came the rather significant matter of an occupation.
Beyond the drinking, however, there is the more significant matter of Moynihan's temperament.
A survey of the academic literature found that declines were important after the age of 50 in areas requiring speed and problem-solving but not where experience and verbal ability were significant (a matter of some comfort for your 53-year-old columnist).The declining importance of manual labour in developed economies could make older workers more productive for longer.
This marks a significant change of subject matter and sourcing for Liu, since Lange is American.
One other experiment has shown a significant "asymmetry" of matter over antimatter.
Now it may figure prominently in determining a number of significant matters, including whether the Earth is experiencing a warming or "greenhouse" trend, the best way to keep power lines free of ice and how best to keep track of ozone levels in the atmosphere.
This implies that as well as luminous matter, there is also a significant amount of dark matter in galaxies that doesn't interact with light in any way.
"It appears that Daschle will have many potential conflicts of interest and will have to recuse himself on a significant number of matters affecting health care and pharmaceutical companies," said David Arkush, director of Public Citizen's Congress Watch, a consumer group.
The firm declines a significant number of matters for which its services are sought".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com