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The phrase "a significant margin in" is correct and usable in written English.
It can be used when discussing differences in quantities, scores, or results, often in competitive contexts such as sports, business, or academic performance.
Example: "The team won the match with a significant margin in points, securing their place in the finals."
Alternatives: "a considerable gap in" or "a substantial difference in".
Exact(9)
Mr. Barak is trailing his right-wing opponent, Ariel Sharon, by a significant margin in the polls.
Sybase trails Oracle, I.B.M. and Microsoft by a significant margin in the database market, according the research firm Gartner.
If the yes campaign wins by a significant margin in Glasgow it will have a serious impact on the overall result.
It requires large industrial customers to file load forecasts each fall for the next calendar year and face a penalty if they are off by a significant margin in either direction.
The state's jobless rate, which exceeded the national average by a significant margin in 1983 when Nissan opened its plant, is now lower — 8.1 percent in June versus 8.2 percent nationwide.
The 30-second spot seeks to cast Mr. Fisher as the underdog, which he is; Mr. Portman leads by a significant margin in recent polls, and has more than $5 million cash on hand, while Mr. Fisher has just over $300,000.
Similar(50)
"There's a significant margin of safety in our portfolio".
That two different mechanical counts produced a difference of about 1,400 votes reveals a significant margin of error in an election that hangs on a mere 300.
It is for these reasons that the MPC [monetary policy committee] judges there to be a significant margin of slack in the economy, even though the extent of that slack, particularly the scope for a productivity rebound, is very uncertain".
The ratio of pixels classified as either myocytes or connective tissue (71.4%), compared with pixels with undefined tissue content (28.6%), was ∼2.5 : 1, suggesting that there is a significant margin for error in the processing approach we used for digitized images from histological sections.
"While that is certainly welcome, the legacy of the financial crisis means that the recovery remains weak by historical standards and there is still a significant margin of spare capacity in the economy, this is most clearly evident in the high rate of unemployment".
More suggestions(15)
a vast margin in
a significant range in
a significant variance in
a significant profit in
a substantial margin in
a significant leeway in
a sizeable margin in
a huge margin in
a sizable margin in
a significant proportion in
a long margin in
a significant partner in
a significant change in
a significant character in
a healthy margin in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com