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The phrase "a significant majority and" is correct and usable in written English.
It can be used when discussing a large portion of a group or population, often in the context of opinions, votes, or decisions.
Example: "In the recent survey, a significant majority and expressed their support for the new policy changes."
Alternatives: "a considerable majority" or "a large majority."
Exact(1)
The Republican speaker of the House, John Boehner, who will go into the next Congress with a significant majority, and McConnell, the incoming Republican majority leader in the Senate, have said Obama would "poison the well" of bipartisan cooperation by taking action on immigration without congressional support.
Similar(59)
Some sub-groups have a significant majority agreement and other have a simple majority agreement.
An overwhelming majority thought chasing cannabis users was "not a police priority", and a significant majority, from all ages and social groups, favoured cannabis decriminalisation.
A fall 2015 pilot of Canvas showed a significant majority of instructors and students would prefer to use Canvas over Classes*v2 (Sakai).
It showed that a significant majority of Ulster Unionist and Sinn Fein supporters want their parties to "jump together" with a simultaneous start to decommissioning of IRA weapons and the formation of an executive body for Northern Ireland, The poll revealed that 63% of the population want decommissioning now, though there were divisions between the two communities on the issue.
Iraq's prime minister, Nuri Kamal al-Maliki, who six months ago said there would be no additional need for United States troops, shifted course earlier this month and said he would support asking American forces to stay if a significant majority of lawmakers and other leaders wanted to keep troops here.
Why do today's conservative Republicans so consistently oppose measures supported by a significant majority of Americans and important to the lives of an overwhelming majority of women?
A month ago, a significant majority in that poll said he should.
Rolls-Royce, which wrote to staff in the run-up to the referendum to say it wanted to remain, said: "Although this is not the outcome the company would have chosen, Rolls-Royce remains committed to the United Kingdom where we are headquartered, directly employ over 23,000 … workers and where we carry out a significant majority of our research and development".
However, the Hall Technique was assessed by GDPs as causing significantly less discomfort compared with conventional restorative techniques, and was preferred to Control restorations by a significant majority of patients, carers and GDPs.
The most glaring of them all is the political apathy present in a significant majority of the population and the inability of our political class to attract and include voters in the political process; the official voter turnout was 37.41%.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com