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The phrase "a significant load of" is correct and usable in written English.
It can be used to describe a large amount or burden of something, often in contexts related to work, stress, or physical weight.
Example: "The project came with a significant load of responsibilities that the team had to manage effectively."
Alternatives: "a considerable amount of" or "a heavy burden of".
Exact(7)
The elimination of many pharmaceuticals in sewage treatment plants (STPs) being often incomplete [3 5], effluents from STPs thus contribute to a significant load of pharmaceutical residues in the receiving waters [6].
Also, high-speed drills, cauterization and ultrasonic aspiration deliver a significant load of thermal energy.
Patients had a significant load of pathogenic bacteria in their sputum as detected by culture methods.
A significant load of endophytic microorganisms in Hemerocallis (Leifert and Cassells 2001) has, to date, effectively restricted this to callus-based systems.
Thus, by101 may have a significant load of spontaneous background mutations due to extended culturing (Eimer et al., 2002; Jarriault & Greenwald, 2002).
For instance, peripheral neuropathy has been found to appear in individuals who bear mutations in just one merlin allele and lack a significant load of potentially compressive Schwann cell tumors [ 9].
Similar(53)
Items were assigned to a factor if pattern coefficient loadings were above ±0.45 and did not cross-load with a significant loading of ±0.3 or above onto any other factor [ 55].
Submission and review of these minor modifications added a significant load to IRB duties of our collaborators, and resultant delays greatly affected our in-country study timelines.
Although S2M1 and S2M2 specimens showed a significant load drop of 33 and 43kN occurred in one step, the beam S2M3 showed significant load drops of 24 and 39 kN occurred in two steps.
Guided by a reference SNP set derived from ANK3, a gene implicated by the Psychiatric Genomic Consortium SZ study, pICA-R identified one pair of SNP and sMRI components with a significant loading correlation of 0.27 (p = 1.64 × 10− 6).
Results of mechanical tests indicated that marble columns were still holding a significant load-carrying capacity despite 23% loss of strength at fire temperature.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com