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The phrase "a significant lesson" is correct and usable in written English.
You can use it when referring to an important or meaningful teaching or insight gained from an experience or situation.
Example: "After reflecting on the challenges we faced, I realized that we learned a significant lesson about teamwork and communication."
Alternatives: "an important lesson" or "a valuable lesson".
Exact(3)
Defeat would have been harsh for everything Tottenham did, but there was still a significant lesson to be learned.
"There is a significant lesson here about the ability of most women to deliver vaginally," said Dr. Jean E. Howe, the chief clinical consultant for obstetrics and gynecology at Northern Navajo Medical Center in Shiprock, N.M.
These commentaries asked, 'Why won't Greeks ask the diaspora for help?' or 'why won't Greeks listen to diaspora Greeks?" or 'Why aren't Greek diaspora communities coming to the rescue?" Before beginning this discussion, it is worth considering a significant lesson from the field of international development, which is, essentially, to first do no harm.
Similar(55)
But perhaps a more significant lesson learned by investors is that, fearful though we all are of future attacks, a far greater risk to our continued prosperity and economic strength comes from within our shores, not without.
Innovation, attention to resource inputs and health outcomes, and prudent use of technology are all significant lessons the US must incorporate to deliver equitable, high-quality health care to the whole population.
While the concordance estimates from population-based twin studies questioned the notion of a major genetic component in type 2 diabetes [ 13], perhaps the most significant lesson from twin studies was the finding that zygosity and thus twin status may influence insulin secretion and insulin action [ 11].
Still, the most significant lesson to be gleaned from the report is perhaps just how rare shootings have become.
In the end, that insistence may be the most significant lesson of this book -- that in the complicated caste and color system of this country, it means something to have a name and to know what that name means.
Oded Distel, director of NewTech, said the most significant lesson Israel can teach India is the Middle Eastern country's unique approach.
To the Editor: The most significant lesson to be learned from the bailout of Fannie Mae and Freddie Mac is that it disproves the idea that free markets can in and of themselves function efficiently without sensible regulations and effective enforcement.
Perhaps the most significant lesson Middelhoff took away from AOL was that the Internet was fundamentally altering the media world, faster even than anyone predicted, and that now was the time for empire building.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com