The phrase "a significant lacuna" is correct and usable in written English.
It can be used to refer to a notable gap or missing part in a text, argument, or body of knowledge.
Example: "The research paper revealed a significant lacuna in the existing literature on climate change impacts."
Alternatives: "a major gap" or "a notable omission."
Hence, there is a general problem with noncognitivist theories, or at least a significant lacuna they leave.
Certainly, Fortune's Fool fills a significant lacuna in our knowledge about Booth and his role in Lincoln's assassination: As Alford points out, no full-length biography has focused exclusively on Booth, despite general recognition that "without a thorough understanding of Booth our knowledge of the murder of Lincoln was lacking" (3).
Although he sometimes downplays the seriousness of this uncertainty [e.g. De Libero Arbitrio III.21.59 and De Genesi ad Litteram, 10.20], there is no getting around the fact that it leaves a significant lacuna at the heart of his philosophical anthropology, one which leaves unanswered crucial questions about how we are to understand the embodied status of the human soul.
A more significant lacuna in this account relates to Elizabeth's religious outlook.
While this material documents many of Lansing's concerns, particularly in his capacity as a lawyer, writer, and public official, there are significant lacunae.
But despite the fact that they have generated considerable interest among philosophers, there remain significant lacunas in our understanding of what models are and of how they work.
The P value map again highlights significant lacunae (green areas in Fig. 7 e ), but in contrast to Model IV significant clusters of label formed far from the injection site (Fig. 7 f, satisfying observation A).
Course content had significant lacunae; for example, the TMs were not taught standard guidelines for differential diagnosis, diagnosis and management of most OIs, and they were not taught to diagnose or manage most severe ADRs.
In theory, we might therefore expect the posterior sections to show a significant difference in empty lacunae compared with the anterior sections.
Particularly with metrics like Mean Lacuna Volume (and correspondingly lacuna dimensions) and spatial distribution, GH plays a significant role and makes inferring the specific differences caused by non-growth-hormone genetic background difficult.
Furthermore, the size of empty lacunae, which presumably contained an actively resorbing osteocyte for a longer period of time prior to cell death, were a significant 26% larger.
