Sentence examples for a significant issue with from inspiring English sources

"The Benghazi thing was such a significant issue with the American people".

It is fair to say that race has not been a significant issue with these acts: not in their lyrics, and not in their audience response.

"In UK health care, workplace bullying remains a significant issue with far-reaching consequences for the health care workforce," the report's authors said.

This isn't a significant issue with chapter books as, once you're delving into the pages, there are few colour illustrations inside anyway.

Determination of the bioaccessible fraction of metals in atmospheric aerosol is a significant issue with respect to air pollution in the urban environment.

Uncertainty associated with the diffusion coefficient, residual water content and first-order decay coefficients is often not a significant issue with respect to the probabilistic outcome; thus, these variables may be treated as deterministic constants.

Wounds are a significant issue worldwide, with over 200M at any one time!

Identification and correction of assay artifacts, which are known to be a significant issue associated with the use of microarray technologies.

Almost 3 decades after the emergence of the HIV epidemic, underdiagnosis of HIV infection remains a significant issue globally, with more than 60% of adult HIV infections remaining undiagnosed in sub-Saharan Africa.

The International League Against Epilepsy (ILAE) Neuropsychiatry commission and United States Institute of Medicine report both identified cognitive and psychological comorbidities as a significant issue for individuals with epilepsy, with rates as high as 60%.

Pain continues to be a significant issue for people with advanced cancer.