The phrase "a significant issue when" is correct and usable in written English.
It can be used to introduce a topic or concern that is important in a specific context or situation.
Example: "A significant issue when implementing new technology is the need for adequate training for all employees."
Alternatives: "a major concern when" or "an important factor when".
Gastric inflation (GI) is a significant issue when ventilation is performed on unprotected airways.
Harvie said that would become a significant issue when Sturgeon needed a majority to push through her next budget.
The problem was his sex life: gay men, Fischer said, have "random, frequent, and anonymous sexual encounters — that becomes a significant issue when we talk about appointing somebody to a post as sensitive as the spokesman for national security".
In order to minimize the loss of alkali elements (a significant issue when analyzing clay minerals), the beam diameter was extended to 200 nm while the counting duration was reduced to 30 s.
Repeated experiments have shown the development time when using ProLIFT becomes a significant issue when patterning PS films above 1-μm thick, as they require a much longer developing time (>60 s) to remove all the ProLIFT in the PS films than typically required for photoresist development (approximately 30 s). Figure 6 Comparison of pore fill techniques utilizing ProLIFT and SOG.
Homosexuals are about short-lived relationships and frequent anonymous sexual encounters...that becomes a significant issue when we're talking about pointing someone to a post as sensitive as national security and foreign policy".
This is a particularly significant issue when estimating prevalence using such methods in communities with recognized limitations in service provisions.
This means that one of the main objections to mandatory voting – the danger of exacerbating the already severe problem of political ignorance – is a much less significant issue when it comes to juries.
' HSAs, HSA supervisors and policy-makers all identified weaknesses in the supervision of HSAs and this was seen as a significant issue particularly when new tasks were being added to HSAs' duties.
In 2008, however, there were no significant issues when Serbia and Croatia played in the Fed Cup, the women's team competition, in the Croatian capital, Zagreb.
But the possibility of disruption in this normal pattern becomes a significant issue at reception point when the choice path contains the options 'mediated: congruent', as it does for P; this is because mediation always leads to the text's 'displacement' from its point of production, and this normally involves the intervention of a mechanical and/or human agency other than the speaker.
