The phrase "a significant issue to" is correct and usable in written English.
It can be used when discussing a matter that is important or noteworthy in relation to a specific subject or context.
Example: "The report highlights a significant issue to consider when developing new policies."
Alternatives: "a major concern for" or "an important matter regarding".
This is a significant issue to people.
Body weight control is a significant issue to pregnant women.
If he does not grant Mr. Newman's severance motion and the defendants are convicted, then one will have a significant issue to argue in an appeal.
As for the hot forming process design of Ti-13Nb-13Zr Ti-13Nb-13Zr Ti-13Nb-13Zr, it is a significant issue to achieve optimized processing parameters corresponding to reasonabiomedicaltitaniums.
A significant issue to be negotiated in Geneva is the nature of the interim authority that would effectively be the trustee for Iraqi interests pending the drafting of a constitution and elections.
Maintenance of good indoor air quality is a significant issue to both the HVAC design engineer and to those who maintain the system subsequent to its design and installation.
In the operation of a virtual team, trust estimation is a very significant issue to know about the trustworthiness of each member and cooperation situations between members.
But perhaps there's a more significant issue to consider here — specific to the smart device category.
The method with the current direction continues to be subject to a significant issue related to the amount of sensors in a distribution system.
Recalcitrance of melanoma to chemotherapy is a significant issue due to limited response rates and lack of predictive biomarkers of chemotherapy benefit.
While the propagation delays are not a significant issue due to the short spatial distances involved, the overall communications latency needs to be addressed for proper real-time control and energy management.
