The phrase "a significant issue of" is correct and usable in written English.
It can be used when discussing a topic or problem that is important or noteworthy in a particular context.
Example: "The report highlights a significant issue of climate change and its impact on global economies."
Alternatives: "a major concern regarding" or "an important matter of".
"It's a significant issue, and I think it's a significant issue of public concern," Blair said.
When it comes to the pay gap there is undoubtedly a significant issue of the period of time a woman spends in unwaged caring for her children.
A significant issue of manifold design, not heretofore considered, is the geometric shape of the exit ports as a means for tailoring manifold performance.
In February 2015 another briefing document noted a "significant issue" of elevated levels of contaminants including lead in fish stock, zinc levels in oysters and lead levels in mussels in three different locations.
Last week the federal health minister Greg Hunt and the prime minister Malcolm Turnbull met with eminent psychiatrist Prof Pat McGorry and other mental health leaders to discuss mental health as a significant issue of national importance.
Development of new nanofabrication methods is always a significant issue of concern.
"This is a significant issue for the city of Pacifica, the county of San Mateo and the state of California," Speier said.
A significant issue for the application of numerical Landscape Evolution Models (LEMs) is their calibration/parameterisation and validation.
The occurrence of fire following earthquakes is a significant issue for buildings in areas of moderate-to-high seismicity.
This is a significant issue for us in light of what many have termed as the "technological singularity".
Stress in the workplace is a significant issue for at least a quarter of the working population in the United States.
