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The phrase "a significant issue in" is correct and usable in written English.
It can be used when discussing a topic or subject that is important or problematic within a specific context.
Example: "Climate change is a significant issue in global politics today."
Alternatives: "a major concern in" or "an important matter in".
Exact(60)
Corrosion under insulation (CUI) is a significant issue in industry.
Assay sensitivity remains a significant issue in pain clinical trials.
Allergic rhinitis (AR) is a significant issue in children.
Overcrowding has been a significant issue in London for many years.
For the first time in memory, family violence is a significant issue in an Australian election.
Cost has become a significant issue in the American states that have legalised physician assisted suicide.
They think that sexual harassment is a significant issue in the workplace.
Seismic retrofitting of existing school buildings is a significant issue in Taiwan.
Patient falls are a significant issue in hospitalized patients and financially costly to hospitals.
Influence maximization for opinion formation (IMOF) is a significant issue in social networks.
Urbanization and aging population has become a significant issue in many global cities.
More suggestions(17)
a considerable issue in
a significant problem in
a significant difficulty in
a prominent issue in
a significant cause in
a significant controversy in
a noticeable issue in
a salient issue in
a tremendous issue in
a tangible issue in
a large issue in
a vital issue in
a significant item in
a notable issue in
a substantial issue in
a significant connection in
a huge issue in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com