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The phrase "a significant issue during" is correct and usable in written English.
It can be used when discussing a problem or concern that occurred within a specific timeframe or event.
Example: "The team faced a significant issue during the project that affected the overall timeline."
Alternatives: "a major concern throughout" or "an important problem during".
Exact(4)
I switched topics, to Dean's support for the death penalty — an anomaly for a "social progressive" (though Bill Clinton was also a death-penalty advocate), and a curiosity because Vermont has no death penalty; nor was it a significant issue during the Dean years.
The high temperatures have been a significant issue during this year's championships with the conditions described as "dangerous" in the opening rounds.
The relative merits of the senses, reason and faith for attaining truth and the guidance of life were a significant issue during this period.
Tephra contamination of grass was still a significant issue during harvest (in April, 3 months after the main tephra fall), prompting a recommendation from JA that fresh grass not be used for feeding animals.
Similar(56)
A significant issue we face during jam processing in households, small-scale or industrial sectors is the negative impact of thermal treatment on the bioactive compounds and consequently, on the antioxidant properties displayed by the obtained products.
A significant issue that we discovered during development was that the copB assay for M. catarrhalis cross-reacted with M. nonliquefaciens and M. lacunata isolates.
"It's a significant issue".
And the cost is a significant issue.
"But it still is a significant issue.
This is a significant issue to people.
Medication safety is a significant issue.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com