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While the pecking order of a state agency might seem like an obscure concern, Senator Kean said that "the chain of command is a significant issue" because it can effect the performance of the state's defense against terrorism.
Besides, the growth at the P2DT 180° bending section is considered a significant issue because of the unexpected achromatic effect.
Lack of empirical results, qualitative or quantitative, was a significant issue because many of the selected ITS are still in development, and hence little was known.
Helsby: Yes, they'll be a significant issue because a lot of the accession countries simply don't have established insolvency procedures or laws or because they're just now in the process of creating them.
This was a significant issue because Internet Explorer 6, the most widely used web browser at the time Acid2 was released, did not support alpha transparency.
This is a significant issue because an increasing volume of evidence indicates that some nephrotoxic substances can have profound effects on renal function, without causing necrosis.
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Analytical differentiation of regioisomers is a significant issue in forensic drug analysis, because, in most cases, legal controls are placed on only one or two of the conceivable isomers.
"This is a very significant issue, because they are playing a game of jeopardy with the protection of property and lives," he said.
Thankfully, this has not been a significant issue in the US because of its general adherence to pluralist values; and because Federal regulations limit the president's ability to leverage special prosecutions as a political tool.
In the interviews, the teachers in three contexts expanded on this view, but the teachers in the distance education context said that cheating was not a significant issue for their courses because of existing strict control of assessment.
This was a significant issue for the NFL, because DATWA only applies to drug testing conducted by "employers" of Minnesota employees.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com