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The endoplasmic reticulum (ER) is the most significant storage site of calcium, and there is a significant interplay between the mitochondrion and ER with regard to calcium.
In the context of the latter possibility, recent findings show a significant interplay between cognition and posture/gait in PD patients [14] [18]).
Previous studies also suggest a significant interplay between patient's physical health and mental health [ 21, 24- 26, 39- 42].
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The HSC niche has diverse functionality, with significant interplay between signalling pathways allowing for the maintenance of a quiescent population of primitive HSC within the bone marrow, as well as subsequent HSC development and differentiation.
The model calculations show that there is significant interplay between homogenous and heterogeneous chemistry.
Given the significant interplay and chemotactic redundancy among chemokines during disease, future work must not only describe the actions of individual chemokines in hypertension, but also characterize how manipulating a single chemokine modulates the expression and/or function of other chemokines and their cognate receptors.
We discuss each of these processes separately to facilitate clarity, but certainly significant interplay will occur amongst these pathways in patients with this disease.
The exact contribution of each of these cell types in RA is unclear but it is likely that the resultant disease is due to significant interplay among these cell populations [ 1].
Each of these processes will be considered separately to facilitate clarity, but we hope the reader will appreciate the significant interplay that may occur amongst these pathways in patients with pulmonary fibrosis.
There is no doubt that, during the complex process of repair and regeneration, significant interplay between haematopoietic and angiogenic factors will be modulating both haematopoiesis and angiogenesis in the bone marrow (Bikfalvi & Han, 1994) and it is unlikely to be explained simply by a single factor.
As pointed out by Ashkarran et al., there is a vast difference between what the biological entities actually "see" when interacting with the NPs versus the actual pristine surface of the NPs, and significant interplay exists between NP properties, type of bacteria, the biological milieu and the observed antimicrobial efficacy.
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