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A significant interaction is found between ERCC1 and BRCA1 mRNA expressions on sensitivity to cisplatin (P = 0.010, n = 45).
This method finds GO categories containing relatively few genes and a significant interaction is not detected in the hypothesis-testing data set.
This is particularly important because the title reports a "gene by environment interaction" whereas no statistical support for a significant interaction is present in this manuscript.
If a significant interaction is found, the treatment effect will be evaluated within strata defined by the covariate interacting with the treatment.
It also is possible that this finding of a significant interaction is due to chance; this warrants further exploration in other studies.
Obtaining sufficient power to find a significant interaction is unlikely in any one cohort (because of small sample size) but is more likely with a meta-analysis or pooled analysis of multiple cohorts (Hunter 2005).
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If a significant interaction were to be found in the derivation sample, its significance would be validated by a decline in AIC value in the validation sample.
However, a significant interaction was observed.
A significant interaction was also found between length and stimulation.
When a significant interaction was found, a post hoc testing was performed to determine pairwise differences.
Duncan's multiple-range test was used for multiple comparisons when a significant interaction was detected.
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CEO of Professional Science Editing for Scientists @ prosciediting.com