The list of all significant interacting pairs for ovarian cancer is described in Additional file 1 Supplemental Table 1 and the list for GBM is also shown in Additional file 1 Supplemental Table 2.
After training, CSIDOP produced a lookup table of significant interacting modular domain patterns from interaction pairs in the training dataset (see Text S1 and Text S2), where each pattern is associated with a number of function terms (please refer to "Material and Method" for details).
Notably, in each of the rest of significant interacting pairs a coordinated way of action is particularly well documented.
Intuitively, several genes (e.g. IL8, DES, RPL30, RBM9 and ENO1) had an unusually higher number of significant interacting genes (encoded by non-red colours), which suggests that they may play a central role in the disease process.
In particular, under the guidance of protein protein interaction network they reported significant interacting SNP pairs for susceptibility to diseases such as hypertension and bipolar disorder.
The results with c35 mutant cells served as a negative control, and indeed, they showed no significant interacting transcription factors at the FDR < 0.10 level.
Finally, the odds ratios (OR) of being either a sprint/power athlete or an endurance athlete were calculated for each significant SNP and significant interacting pairs of SNPs using the best genetic model for each SNP.
K-GIDDI accomplishes the task by gathering functionally related PPIs into a 'group' from which it derives the most representative and significant interacting domain (DDI) pattern that could explain the set of PPIs within that group.
