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The phrase "a significant indication to" is correct and usable in written English.
It can be used when you want to express that something serves as an important sign or signal regarding a particular subject or situation.
Example: "The recent data provides a significant indication to the effectiveness of the new policy."
Alternatives: "a strong indication of" or "a notable sign of".
Exact(1)
As such, pregnancy represents a significant indication to optimize therapy and maximize lung function in order to reduce the risk of acute exacerbation and resultant adverse health outcomes.
Similar(59)
Still, supporters and detractors of the project said the vote -- six members in favor, one against, with one abstention and the chairman of the council not voting -- was a significant indication that the council has warmed to the notion of the cable.
Usually, samples are collected indirectly by clean-voided midstream urine, and growth of the same uropathogen (≥10 cfu/ml) in two consecutive specimens is considered to be a significant indication of the presence of bacteria in bladder urine (3).
However, it is equally important to ask, in view of the guidance published by NICE, whether social deprivation is a significant indication of perceived psychological and social difficulties among cancer patients.
WASHINGTON — In a significant indication of where the Army anticipates it will be deployed over coming years, and what it will be doing there, the service is planning to relocate some of its vast overseas stores of combat equipment and alter the contents of other warehouse stocks to reflect the changing nature of the mission after the wars in Iraq and Afghanistan.
The segments jump is a significant indication of an increase in business spending as the economy makes its way out of the worst recession since World War II.
Retention of inner lumen diameter at two weeks is a significant indication of lowered stenosis risks.
Of the three neutrality tests employed, only the Fs test showed a significant indication of an expansion (Table 3).
1179 single-read GSS sequences and 502 EST contigs yielded matches with E values better than e-5, which were considered a significant indication of a coding sequence.
Serous atrophy of subepicardial and bone marrow fat is considered a significant indication of lack of energy as the immediate cause of death [ 1].
The interaction of VEGF-C expression with treatment provides a significant indication for a possible predictive role of mRNA expression of VEGF family members, a role that warrants further evaluation in larger studies.
More suggestions(17)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com