The phrase "a significant implication when" is correct and usable in written English.
It can be used to introduce a discussion about the important consequences or effects that arise in a specific context or situation.
Example: "There is a significant implication when we consider the long-term effects of climate change on global economies."
Alternatives: "a major consequence when" or "an important effect when".
The existence of a "neuron-specific" Thap1 species that binds DNA has significant implications when thinking about how mutations in a ubiquitously expressed gene result in a neurologic disease without obvious pathophysiology in other organs.
This lack of understanding that comes from learning about basic genetic science from popular media might have significant implications when communicating information to patients, even during routine healthcare.
This may have significant implications when considering therapeutic strategies for treating IVD degeneration and inflammatory pain development, and may, therefore, warrant further investigations into the possible clinical benefits of using MAP kinase inhibition for treating this debilitating disease.
BRAF heterogeneity has significant implications when using RAF kinase inhibitors because, in contrast to BRAFV600E melanoma cells, BRAF wild-type cells are resistant to (and may even be stimulated by) RAF kinase inhibitors (Hatzivassiliou et al, 2010; Heidorn et al, 2010).
The finding that microglia/macrophages account for the TSPO signal may be of limited importance for diagnostic purposes but may have significant implications when this radioligand is employed for assessment of treatment response to i.e. radiotherapy or combined radio- and chemotherapy.
Finally, we emphasize that validation of the hypothesis that stem cells can adapt their aneuploidy rate through a diversification factor would have significant therapeutical implications, when specialized to cancer stem cells.
The model proposed is in an Australian context, yet has significant implication for communities at all levels when planning for places for people.
As TSR search engines become more flexible and thorough, educational institutions and even the law also need to adapt to combat plagiarism as a grave threat to educational quality and an ethical problem with significant socio-economic implications when students graduate as habitually dishonest or seriously incompetent "professionals".
"So in my view there is a significant resource implication here".
