The phrase "a significant impact upon" is correct and usable in written English.
It can be used when discussing the effects or influence of one thing on another, often in formal or academic contexts.
Example: "The new policy is expected to have a significant impact upon the local economy."
Alternatives: "a considerable effect on" or "a major influence over".
"Such provisions could have a significant impact upon journalists, whistleblowers, and civil society," he says.
This procedure has a significant impact upon the defendant's Fourteenth Amendment rights.
"About a third of our prison population are remandees, which has a significant impact upon our numbers.
As PR manager she has helped me make decisions that have had a significant impact upon the success of the business.
The percent content of the conductive filler has a significant impact upon EMI SE of the composites.
Thermal properties of lithium ceramic pebble beds have a significant impact upon the thermal performance of the fusion blanket.
It is shown that experimental design (sample and reference arrangements) has a significant impact upon the derived data.
Felicity Wishart, campaign director at the conservation society, said the planned increase in dredging could have a significant impact upon the reef.
Because the remedial treatment of contemporary art works can have a significant impact upon their resale value, and upon their attractiveness to museum curators, Scheidemann's work is, of necessity, cloaked in discretion.
"But alcohol also has a significant impact upon the wider urgent care system, with countless presentations at walk-in centres, urgent care centres and minor injury units," the report says.
The National Demonstration Project would not only benefit the teachers and students in those communities; it would also establish a potentially expandable network of Teachers Institutes that should have a significant impact upon education reform throughout this nation.
