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The phrase "a significant impact in" is correct and usable in written English.
It can be used when discussing the effects or influence of something in a particular area or context.
Example: "The new policy is expected to have a significant impact in improving employee productivity."
Alternatives: "a considerable effect on" or "a major influence in".
Exact(60)
All this could have a significant impact in the US.
This evidence-based approach already has had a significant impact in the marketplace.
But recently we realised that selling the drinks ready-made has a significant impact in revenue.
"Nuclear power has a significant impact in our lives," Mr. Koizumi said Tuesday.
International commercial interests often have a significant impact in worsening environmental issues".
Darren Bennett, punter The first Australian to make a significant impact in the NFL.
But several Giants players said Way has already had a significant impact in his new job.
The secretary said that the United States has already had a significant impact in Iraq.
Local victories have had a significant impact in pushing back against the epidemic and saving lives.
Broadband would have a significant impact in reducing the level of poverty," she said.
Below, you can find various foods that have made a significant impact in our life today.
More suggestions(18)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com