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The phrase "a significant impact and" is correct and usable in written English.
It can be used when discussing the effects or consequences of an action, event, or phenomenon, often in a formal or academic context.
Example: "The new policy is expected to have a significant impact and improve overall productivity in the workplace."
Alternatives: "a considerable effect and" or "a notable influence and".
Exact(26)
Kids need to be taught, so it's a significant impact, and expensive, because cover teachers cost a lot of money.
"Those actions have had a significant impact, and companies are paying attention," an agency official said yesterday.
Challenging burglary patterns recently emerged in Nassau County, and through hard work our investigators have made a significant impact and reduced the number substantially.
Neither has had a significant impact and, while Emery says Sevilla plan to exercise their option to buy Aspas, insisting "next year could be his year", it seems unlikely that Deulofeu will continue.
Heather Grabbe, director of the Open Society Institute in Brussels, said two striking features of the elections were the failure of the left to make a significant impact and the advances by the far-right and other fringe parties.
Given 41% of prisoners reported having observed violence in the home and 29% reported emotional, sexual or physical abuse as a child, mindfulness could have a significant impact and affect the higher one-year recidivism rates among these groups".
Similar(34)
The harms caused can be grave and have a significant impact on victims and society.
This scale means Unilever has a significant impact on communities and the environment, and so their ambitions also need to be of such a scale.
MRGN are responsible for serious infections and have a significant impact on morbidity and mortality [ 2].
Other bands led by Asian women followed, like Blonde Redhead and Deerhoof, having a significant impact on indie and alternative music.
Snapchat experts agree Snapchat is growing rapidly and is making a significant impact on businesses and its users.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com